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Join us on 12-15-2022 for a live seminar about RNA SEQ
Join us on 12-15-2022 for a live seminar about RNA SEQ
We envision a future in 20 years where soluble TCR modalities become as common of a treatment paradigm as antibodies are today. Keyway unites innovative minds in antibody discovery with the pioneering minds behind TCR therapeutics, to provide comprehensive, proprietary technology and capabilities for end-to-end discovery of TCR mimics (TCRms) and engineered TCRs.
TCRms are antibodies that have been developed to target peptides presented on the cell surface in the context of major histocompatibility complexes (pMHCs), opening up a wide range of intracellular targets, including novel cancer targets. Keyway‘s robust TCRm discovery services is an end-to-end solution from target idea to final panel of therapeutic leads. We start with high-quality pHLA generation for discovery and optimization and complete campaigns with in vitro and in silico specificity testing to reduce the off-target effects that can limit many TCRm therapeutics in the clinic.
Proprietary protocols, workflows, know-how, technology, and materials for the consistent generation of high-quality pMHC complexes, giving you the high-quality antigens that are crucial for the generation of high-quality therapeutic leads.
Alloy’s full suite of in vivo, in vitro and in silico antibody discovery capabilities are tailored to identifying and optimizing a diverse set of antibodies that bind to a specific pMHC complex. This approach selects for non-specific binders to related pMHC complexes while also using Alloy’s AI/ML workflows to reduce genome-wide polyreactivity.
We leverage pMHC phage and eukaryotic display libraries for specificity testing to address off-target non-specificity effects, to give you greater confidence that Keyway-generated therapeutic candidates are successful as they advance to clinical trials.
Dongxing Zha, PhD, CTO of TCR Discovery & Engineering and CEO of Keyway TCR Discovery
Keyway offers additional TCRm engineering into your preferred output of choice and integrates closely with our Translational Medicine offering for in vivo and in vitro functional testing.
Multiple proprietary T-cell engagers (including CD3 and CD28) and high-throughput bispecific generation and screening.
mRNA- and lentiviral-based vector system producing CAR-Ts and characterization.
Translational Medicine gives early insights into the functional activity of candidates generated from Keyway TCR discovery projects.
Our phage display for soluble TCRs workflow will leverage our proprietary optimized synthetic phage library designed to expand the sequence space beyond natural repertoire, followed by a transgenic humanized mouse in vivo discovery platform optimized for human TCR-based therapeutics.
Learn about our latest product updates, events, and TCR discovery collaborations.
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— Agreement provides Scripps Research scientists with broad access to Alloy’s fully human transgenic mouse platform, which has the power to increase the pace and success rate of antibody discovery and vaccine development efforts. —
Alloy Therapeutics is a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Through a community of partners across academia, biotech, and the largest biopharma, Alloy democratizes access to pre-competitive tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics across six modalities: antibodies, TCRs, genetic medicines, peptides, cell therapies, and drug delivery. Partners may access all current and future technologies through a discovery service relationship or for a flat fee through Alloy’s Innovation Subscriptions offering. As a reflection of Alloy’s relentless commitment to the scientific community, Alloy reinvests 100% of its revenue in innovation and access to innovation.
Join the Alloy Therapeutics community by visiting alloytx.com and following Alloy on LinkedIn.
About Scripps Research
Scripps Research is an independent, nonprofit biomedical institute ranked one of the most influential in the world for its impact on innovation by Nature Index. We are advancing human health through profound discoveries that address pressing medical concerns around the globe. Our drug discovery and development division, the Calibr-Skaggs Institute, works hand-in-hand with scientists across disciplines to bring new medicines to patients as quickly and efficiently as possible, while teams at Scripps Research Translational Institute harness genomics, digital medicine and cutting-edge informatics to understand individual health and render more effective healthcare. Scripps Research also trains the next generation of leading scientists at our Skaggs Graduate School, consistently named among the top 10 U.S. programs for chemistry and biological sciences. Learn more at scripps.edu.
Chris Bedi
communications@alloytx.com
BOSTON, Mass., May 21st, 2024 – Alloy Therapeutics, a biotechnology ecosystem company dedicated to democratizing access to biologics drug discovery platforms and services, announced today a licensing agreement for its murine platforms for fully human antibody discovery with Eli Lilly and Company. The non-exclusive license provides Lilly access to the ATX-Gx™ and ATX-CLC™ mouse platforms and broad rights to use the Alloy platforms for antibody drug discovery and development under this multi-year collaboration.
Launched in 2019, the Alloy ATX-Gx platform has rapidly become the industry standard fully human transgenic mouse platform to enable therapeutic discovery programs utilized by over 170 partners. Alloy is dedicated to reinvesting its revenue into innovation and has continuously expanded its murine platforms, adding new strains such as ATX-GL™ with the full human lambda repertoire as well as ATX-GKH™ hyperimmune strain for increased generation of antigen-specific B-cells and enhanced IgG class switching. In 2023 Alloy launched the ATX-CLC platform expressing common light chain antibodies with full heavy chain diversity to enable efficient, modular bispecific discovery.
Access to Alloy’s platforms extends to Lilly’s Catalyze360™ program, a comprehensive platform designed to enable drug discovery and development for biotech partners, including opportunities for capital investment, world-class lab space, and exceptional R&D capabilities and expertise. Under the arrangement, biotech companies that work with Lilly Catalyze360 will have the opportunity for Alloy antibody discovery platforms to be deployed to rapidly progress partnered discovery campaigns and accelerate medicines to the clinic for patients.
“Lilly is a great collaboration partner, and we are excited to further enable the company’s broader R&D ecosystem with access to Alloy’s best-in-class technologies for discovering superior fully human antibodies and bispecifics against even the most challenging targets,” said Heather Schwoebel, CBO of Antibodies and Strategic Collaborations at Alloy. “This collaboration represents just one example of the many ways Alloy is flexible in enabling our partners with a breadth of discovery solutions to support their objectives and improve patient lives.”
About Alloy Therapeutics
Alloy Therapeutics is a biotechnology ecosystem company empowering the global scientific community to make better medicines together. Through a community of partners across academia, biotech, and the largest biopharma, Alloy democratizes access to pre-competitive tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics across six modalities: antibodies, TCRs, genetic medicines, peptides, cell therapies, and drug delivery. Partners may access all current and future technologies through a discovery service relationship or for a flat fee through Alloy’s Innovation Subscriptions offering. As a reflection of Alloy’s relentless commitment to the scientific community, Alloy reinvests 100% of its revenue in innovation and access to innovation.
Join the Alloy Therapeutics community by visiting alloytx.com and following Alloy on LinkedIn.
Russell Beckerman
communications@alloytx.com
Through our collaboration with leading antisense inventor Sudhir Agrawal, we are offering proprietary compounds that enable RNA-based therapeutics to avoid off-target effects of the past and actively engage the immune system for therapeutic effect. License these for use in your ASO discovery efforts to turn your RNA biology into viable therapeutic formats.
We offer these licenses at preferred terms to spur your innovation efforts
We’ll work together to find you the best therapeutic TCRm to achieve your cancer immunotherapy pipeline goals.
Explore:
Our research facilities:
Boston, MA
Cambridge, UK
Basel, CH
Athens, GA
© 2023 Alloy Therapeutics, Inc. All Rights Reserved.
Thanks for your interest in our white paper, Targeting GPCRs with DeepImmune Antibody Discovery.
G protein-coupled receptors (GPCRs) play a central role in multiple physiological functions, from endocrine sensing to neurotransmission to chemotaxis of immune cells. This class has long been an attractive target for novel antibody drug discovery campaigns in multiple disease indications, but their unique nature produces many challenges for in vivo antibody discovery. In this white paper, we detail how our humanized mouse discovery platform, the ATX-Gx™, have been successfully utilized for GPCR-targeted antibody discovery, Alloy Antibody Discovery’s DeepImmune™ module builds on this robust in vivo discovery platform, coupling best-in-class immunogen production with multiple binder recovery approaches, and advanced machine-learning-based techniques for lead identification and optimization.
I’d like more material about Keyway TCR Discovery
Thanks for your interest in our recent Keyway TCRm Discovery webinar, Increasing Target Specificity and Tackling Intracellular Targets for TCRm Therapeutics Development with Keyway’s TCRm Discovery Offering. In it, the team at the helm of our TCR mimic discovery campaigns shared:
1. An overview of common challenges to intracellular protein-targeting drug discovery
2. Keyway’s industry-leading solutions to TCRm/TCR-based therapeutic discovery including its proprietary specificity screening and high-quality pMHC complex antigen production capabilities
3. A case study featuring the discovery of a panel of highly specific, functional TCRm binders against an intracellular immuno-oncology target
Upon filling out this form, you will receive an email with a link to the webinar recording.
