Join us on 12-15-2022 for a live seminar about RNA SEQ
Genetic Medicine modalities promise to reach intracellular disease targets at the nucleic acid level that are undruggable by conventional modalities. But the success of these therapeutics has been limited by therapeutic index and delivery challenges. Alloy offers foundational technologies and discovery capabilities that address these issues for creating antisense oligonucleotide (ASO) drug candidates.
Leveraging our collaboration with Sudhir Agrawal, a pioneer of antisense technology including gapmer, we have developed an advanced format, AntiClastic™ Antisense Oligonucleotides (AntiClastic™ ASOs), which addresses the limitations of antisense therapeutics. Sudhir is the founder of Arnay Science and the chair of Alloy’s Genetic Medicines SAB.
Uses established building blocks, optimal use of 3’- and 5’ ends, and optimal engagement of RNaseH for precise excision.
Leverages proprietary structures to improve potency and promote the delivery of antisense to target RNA.
Minimizes off-target interactions with unintended RNA targets , mitigates the inflammatory response—thereby improving the therapeutic index.
We have demonstrated significant enhancement in potency by converting known antisense sequences to our proprietary AntiClastic ASO Format.
We collaborate closely with our partners to create, improve, and share offerings that enable the discovery of novel AntiClastic ASO therapeutics for your therapeutic pipelines.
You provide Alloy with the gene target, and we create drugs by applying our bioinformatics solutions and AntiClastic ASO format to discover the lead sequences. We provide guidance and generate preclinical data.
You provide Alloy your lead antisense sequence, and we apply our new AntiClastic ASO format to generate leads with improved potency.
Our partnership model allows us to share risk and success, while our flexible research and partnership terms offer collaborators of all sizes to access Alloy’s platform and technology with ease.
The term AntiClastic describes our innovative strategy of combining the improvements in the primary sequence with a novel spatial conformation of nucleic acid drugs. Our novel structure brings nucleic acids together for an advanced, proprietary format that further enhances the drug-like properties of antisense. (From the Greek anti-, “opposite” and klastos, “broken in pieces”.)
Learn about our latest product launches and partnership collaborations in genetic medicines .
Learn about our latest product launches and partnership collaborations in Genetic Medicines .
Learn how to get started with our proprietary AntiClastic ASO therapeutic formats or develop a bespoke discovery project together.
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Our research facilities:
Boston, MA
Cambridge, UK
Basel, CH
Athens, GA
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Thanks for your interest in our white paper, Targeting GPCRs with DeepImmune Antibody Discovery.
G protein-coupled receptors (GPCRs) play a central role in multiple physiological functions, from endocrine sensing to neurotransmission to chemotaxis of immune cells. This class has long been an attractive target for novel antibody drug discovery campaigns in multiple disease indications, but their unique nature produces many challenges for in vivo antibody discovery. In this white paper, we detail how our humanized mouse discovery platform, the ATX-Gx™, have been successfully utilized for GPCR-targeted antibody discovery, Alloy Antibody Discovery’s DeepImmune™ module builds on this robust in vivo discovery platform, coupling best-in-class immunogen production with multiple binder recovery approaches, and advanced machine-learning-based techniques for lead identification and optimization.
I’d like more material about Keyway TCR Discovery
Thanks for your interest in our recent Keyway TCRm Discovery webinar, Increasing Target Specificity and Tackling Intracellular Targets for TCRm Therapeutics Development with Keyway’s TCRm Discovery Offering. In it, the team at the helm of our TCR mimic discovery campaigns shared:
1. An overview of common challenges to intracellular protein-targeting drug discovery
2. Keyway’s industry-leading solutions to TCRm/TCR-based therapeutic discovery including its proprietary specificity screening and high-quality pMHC complex antigen production capabilities
3. A case study featuring the discovery of a panel of highly specific, functional TCRm binders against an intracellular immuno-oncology target
Upon filling out this form, you will receive an email with a link to the webinar recording.