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Alloy Genetic Medicine Discovery

Creating transformative Genetic Medicines leveraging our new proprietary format, AntiClastic™ Antisense Oligonucleotides (AntiClastic™ ASOs).

PROPRIETARY FORMATS FROM ASO PIONEERS

Addressing Unmet Clinical Needs with Genetic Medicines

Genetic Medicine modalities promise to reach intracellular disease targets at the nucleic acid level that are undruggable by conventional modalities. But the success of these therapeutics has been limited by therapeutic index and delivery challenges. Alloy offers foundational technologies and discovery capabilities that address these issues for creating antisense oligonucleotide (ASO) drug candidates.

ENABLING DRUG DISCOVERY OF:
ANTICLASTIC ASO FORMAT
ANTICLASTIC ASO DISCOVERY SERVICES
ANTICLASTIC™ ANTISENSE OLIGONUCLEOTIDES

Alloy’s Proprietary, Widely Applicable Antisense Format for Creating Better Drugs

Leveraging our collaboration with Sudhir Agrawal, a pioneer of antisense technology including gapmer, we have developed an advanced format, AntiClastic™ Antisense Oligonucleotides (AntiClastic™ ASOs), which addresses the limitations of antisense therapeutics. Sudhir is the founder of Arnay Science and the chair of Alloy’s Genetic Medicines SAB.

LEARN ABOUT THE PARTNERSHIP
Precise Design

Uses established building blocks, optimal use of 3’- and 5’ ends, and optimal engagement of RNaseH for precise excision.

Improved Potency

Leverages proprietary structures to improve potency and promote the delivery of antisense to target RNA.

Alloy AntiClastic Antisense Oligonucleotides
Better Medicines

Minimizes off-target interactions with unintended RNA targets , mitigates the inflammatory response—thereby improving the therapeutic index.

CASE STUDY

Alloy’s Novel Antisense Format Improves Potency

We have demonstrated significant enhancement in potency by converting known antisense sequences to our proprietary AntiClastic ASO Format.

AntiClastic ASO Format Improved Drug Potency by Up to 25-Fold

ANTICLASTIC ASO DISCOVERY SERVICES

Alloy Discovers the Best AntiClastic ASO Therapeutics for Our Partners

We collaborate closely with our partners to create, improve, and share offerings that enable the discovery of novel AntiClastic ASO therapeutics for your therapeutic pipelines.

Discovery of Antisense Leads in AntiClastic ASO Format

You provide Alloy with the gene target, and we create drugs by applying our bioinformatics solutions and AntiClastic ASO format to discover the lead sequences. We provide guidance and generate preclinical data.

Alloy AntiClastic Antisense Oligonucleotides

Applying AntiClastic ASO Format to Existing Antisense Sequences

You provide Alloy your lead antisense sequence, and we apply our new AntiClastic ASO format to generate leads with improved potency.

Flexible Project Scopes and Partnership Terms

Our partnership model allows us to share risk and success, while our flexible research and partnership terms offer collaborators of all sizes to access Alloy’s platform and technology with ease.

NOVEL SPATIAL CONFORMATION

Why we call our format AntiClastic

The term AntiClastic describes our innovative strategy of combining the improvements in the primary sequence with a novel spatial conformation of nucleic acid drugs. Our novel structure brings nucleic acids together for an advanced, proprietary format that further enhances the drug-like properties of antisense. (From the Greek anti-, “opposite” and klastos, “broken in pieces”.)

NEWS AND ANNOUNCEMENTS

Alloy Genetic Medicines News & Updates

Learn about our latest product launches and partnership collaborations in genetic medicines .

News and announcements

Alloy Genetic Medicines News & Updates

Learn about our latest product launches and partnership collaborations in Genetic Medicines .

Let’s make better Genetic Medicines together

Learn how to get started with our proprietary AntiClastic ASO therapeutic formats or develop a bespoke discovery project together.

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