Alloy is Building the World's First Fully Integrated Product Development
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AI/ML • Alloy Insights
AI/ML Built Into the Alloy Discovery & Development Engine
- EXPLORE AI/ML
THE PLATFORM
Enabling teams to get from an idea to human data for less than $10M
Trained on one of the industry’s largest in-house experimental datasets, our models improve predictions and shorten cycles. By unifying software with our global wet-lab engine, we enable teams to get from an idea to human data for less than $10M.
Our Capabilities
Integrated AI for real biological outcomes
Alloy Therapeutics unites proprietary in vivo discovery platforms with state-of-the-art AI/ML to deliver more predictable, more potent, and more developable therapeutic antibodies.
Our integrated workflows don’t just screen for what exists—they actively design what should exist, pairing in silico prediction with rapid wet-lab validation to move programs from idea to insight with unprecedented speed and precision.
Deep Repertoire Intelligence
We go beyond traditional random screening to computationally analyze immune responses from ATX-Gx™ mice, mining the full richness of the repertoire.
SmartSelect recovers a high rate of binders from
NGS repertoirs with diverse epitopic coverage.
SmartSelect™
Advanced NGS informatics and proprietary algorithms surface diverse, epitope-spanning clones that often remain invisible to standard approaches.
Liability Detection
Early identification of glycosylation sites, unpaired cysteines, and sequence-based liabilities ensures only the most developable candidates advance.
Repertoire Visualization
AI-powered mapping reveals high-value clusters and optimized variants across thousands of clonotypes.
Generative Design & High-Precision Optimization
Our AI/ML toolkit includes protein language models, diffusion models, Bayesian optimization engines, and guided mutational strategies.
Majority of round 2 leads show improved affinity (KD<500 pM) and reduced hydrophobicity.
ACE: AI-guided Clonotype Expansion
AI-guided Clonotype Expansion and Iterative Design generate and prioritize libraries tailored to affinity, specificity, or function.
Affinity Engineering
Bayesian optimization focuses the search space, delivering dramatic improvements—in internal programs, >20× affinity gains from nano- to picomolar.
Targeted Property Tuning
Precisely engineer for pH-dependent binding, species cross-reactivity, stability, or custom functional behavior.
The Power of Integration: AI × mAbForge™
Alloy’s AI becomes most powerful when paired with mAbForge™, our high-throughput expression and characterization engine.
- Rapid expression and testing ~180 genAI designed variants per round
- After 2 rounds, antibodies affinities had improved to < 100 pM and functional potency was better than clinical comparators
A Closed Design–Build–Test Loop
Experimental data continuously trains and refines our models. Learnings compound quickly—binding data in 2–3 weeks.
Hard-to-Drug Targets
AI-informed immunogen design, together with our in vivo discovery platforms, unlocks targets historically inaccessible to traditional methods (e.g., GPCRs, ion channels).
End-to-End Platform
From immunization through optimization and developability screening, we provide a unified ecosystem for accelerating candidate selection.
Predictive Developability
We help teams fail fast and succeed faster by predicting manufacturability and formulation outcomes before wet-lab work begins.
Structural modeling to identify potential causes of any assay flags
Computational Developability Scoring
Models assess viscosity, hydrophobicity, aggregation risk, and other biophysical parameters early in design.
Structural Modeling at Scale
Automated structural modeling for 1000+ antibodies per campaign, enabling ranking and triage across complex libraries with predicted biophysical properties.
CASE STUDY
How AI/ML optimized a therapeutic antibody
Discover how Alloy’s AI/ML platform integrates with our discovery ecosystem—from repertoire mining and generative design to predictive developability and mAbForge™ validation.
Bring AI/ML to your next antibody program
Bring your program to a team that pairs proprietary in vivo platforms with AI/ML at every step. We work with biotech, pharma, and academia to move from idea to high-quality candidates faster, and with more confidence.
